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Coming off a weekend sweep at Detroit, Chicago has won five straight for the first time since Aug. 10-14, 2006. The White Sox have won six of their last seven home openers.
Crede is batting .393 with 10 RBIs. Last year, limited to 47 games because of a back injury, he hit .216 with 22 RBIs. With Josh Fields also available to play third, Chicago explored trade opportunities for Crede during much of the offseason.
Jermaine Dye tied the score at 3 with a one-out RBI single off Pat Neshek, who had just relieved Matt Guerrier (0-1). A.J. Pierzynski struck out, and Carlos Quentin loaded the bases with a single.
Crede drove a 1-0 pitch to the bullpen in left for the fifth slam, his first since June 24, 2006, against Houston.
Chicago's Javier Vazquez (1-1) struggled early before settling into a rhythm, and allowed three runs and seven hits in seven innings, striking out eight and walking one. Bobby Jenks pitched a scoreless ninth for his fourth save in as many chances.
White Sox manager Ozzie Guillen was ejected after plate umpire Phil Cuzzi called a second strike against Paul Konerko during the third inning. Guillen went nose-to-nose with the umpire for several minutes as the crowd chanted "Ozzie! Ozzie!" The ejection was Guillen's 13th since becoming Chicago's manager in 2004.
Twins rookie Nick Blackburn allowed two runs and seven hits in five innings.
[Associated Press; By ANDREW SELIGMAN]
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