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Brian Roberts had three hits, but Baltimore stranded 11 and went 2-for-11 with runners in scoring position.
"We had some opportunities and Matsuzaka made some big pitches and got out of them," Orioles manager Dave Trembley said. "But we hung in there the best we could. When your team's playing good, everything seems to go your way. And when it's not going your way, it seems like guys out in the field got extra gloves on."
The Red Sox used an RBI single by David Ortiz and a sacrifice fly by Jason Bay to go up 2-0 in the first inning, and Varitek homered leading off the second.
Baltimore closed to 3-2 in the third. After Matsuzaka retired the first two batters, Melvin Mora singled and Aubrey Huff walked before Ramon Hernandez and Luke Scott delivered run-scoring singles.
The Orioles loaded the bases in the fourth before Matsuzaka struck out Mora and retired Huff on a popup.
"We had the right guys up there and it didn't happen," Trembley said.
Opponents are 0-for-14 against Matsuzaka this season with the bases loaded.
"Now that you said it, I think someone's going to get that hit," he said. "It doesn't matter whether the bases are loaded or not, my job is to not allow the runners to score. If there's a base empty, of course, it's a little easier. But it's not something I worry about."
Notes: The sellout crowd of 48,515 was the largest of the season and included the 50 millionth fan at Camden Yards. The 17-year-old stadium reached 50 million quicker than any ballpark in baseball history. ... RHP Josh Beckett's next start for Boston has been pushed back a few days because of lingering numbness in his right hand. ... Boston rookie Jacoby Ellsbury stole two bases to raise his AL-leading total to 40.
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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