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Blake was 0-9 in five-set matches before a second-round victory here last year. He's now 4-11 all-time in matches that go the distance, including 2-4 at the Open. It was Young's first career five-setter.
The women's draw is even more tricky, now that 2007 champion Justine Henin has retired and Maria Sharapova is out with an injured shoulder.
Six different women have won the U.S. Open in the last seven years, and Dementieva is seeking her first major championship. To her, the Olympic singles title counts.
"The biggest goal for the year was Beijing," she said. "In Russia, if you stop anyone in the street and ask what is a Grand Slam, I don't think many people can tell you. But everyone knows the Olympic Games. There is nothing bigger."
Dementieva put together a workmanlike win over Amanmuradova. Her opponent from Uzbekistan served for the second set ahead 5-3, but Dementieva still had enough energy.
"I don't know what is best, to be a little bit tired but very comfortable and very positive, or to be fresh and not play in the Olympic Games," she said.
No. 2 seed Jelena Jankovic advanced with a 6-3, 6-1 victory over American CoCo Vandeweghe.
Li Na, who defeated Venus Williams in Beijing, beat No. 24 Shahar Peer of Israel 2-6, 6-0, 6-1. The No. 23-seeded Davenport defeated Aleksandra Wozniak of Canada 6-4, 6-2, and No. 3 Kuznetsova beat Zhang Shuai of China 6-4, 6-2.
No. 8 Vera Zvonareva of Russia, No. 12 Marion Bartoli of France, No. 14 Victoria Azarenka of Belarus and No. 15 Patty Schnyer of Switzerland also won.
No. 22 Maria Kirilenko of Russia lost to Tamira Paszek of Austria 6-3, 3-6, 6-4.
On the men's side, fourth-seeded David Ferrer of Spain beat Martin Vassallo Arguello of Argentina 7-6 (1), 6-2, 6-2 and No. 6 Andy Murray of Britain beat Sergio Roitman of Argentina, 6-3, 6-4, 6-0.
Also winning were No. 7 David Nalbandian of Argentina, No. 10 Stanislas Wawrinka of Switzerland, No. 16 Gilles Simon of France and No. 17 Juan Martin del Potro of Argentina.
No. 27 Feliciano Lopez of Spain lost to Jurgen Melzer of Austria 4-6, 7-6 (5), 6-2, 2-6, 6-4. The No. 29-seeded Juan Monaco of Argentina lost to Kei Nishikori of Japan 6-2, 6-2, 5-7, 6-2.
[Associated Press;
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