Lee became the eighth pitcher since 1920 to win 19 of his first 21 decisions in a season, according to Stats LLC. The last to do it was Roger Clemens, who was 20-1 after beating the White Sox on Sept. 19, 2001, while with the Yankees.
Chris Lambert (0-1) gave up six runs -- two earned -- and five hits in 2 2-3 innings in his major league debut for the Tigers. Lambert's contract was purchased from Triple-A Toledo earlier on Tuesday.
The Indians used the longball and two Tigers errors to score six in the third. Carroll and Shoppach led off with back-to-back home runs. Carroll's was his first since last Aug. 11.
Lambert then hit Orlando Cabrera with a pitch. Cabrera stole second and came home on third baseman Ryan Raburn's error on a groundball by Franklin Gutierrez. One out later, Jhonny Peralta singled and Guttierez scored when the ball skipped past left fielder Marcus Thames for an error and rolled to the fence.
Peralta later scored on David Dellucci's double, and Carroll chased Lambert with an RBI single.
Francisco's first two-run homer, in the fourth, made it 8-0. He added a second in the seventh inning and has 14 on the season.
The Tigers got on the board in the fifth on Raburn's run-scoring double and Brandon Inge's RBI single, and scored two more on Renteria's ninth-inning home run.
Grady Sizemore, a night after becoming the 14th American League player to join the 30-30 club, went 0-for-4.
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