The Lakers lost their second in a row to another of the NBA's lesser teams, having been beaten by Charlotte on Wednesday night. The latest loss kept them from joining New Orleans and San Antonio in a three-way tie for the Western Conference lead.
Bryant scored 50 or more points for the 23rd time and the second this month. He had 52 against Dallas on March 2. The Lakers fell to 16-7 when he goes for that many.
He was limited to six points in the fourth quarter, when the Lakers nearly erased all of a 10-point deficit. He had 10 rebounds and one assist while taking 37 of the Lakers' 104 shots. They attempted a franchise record 45 3-pointers, making 15.
Darko Milicic had 22 points and 12 rebounds, Hakim Warrick 16 points, Kyle Lowry 11 and Mike Miller 10 points and 10 rebounds for the Grizzlies, who are 6-30 on the road and 2-20 away from home against Western Conference teams.
The Grizzlies led by 10 early in the fourth, their largest lead of the game.
Sasha Vujacic hit a 3-pointer to cut the Lakers' deficit to 109-106 with 3:03 remaining. Miller missed a 3-pointer, but the Lakers couldn't convert on their end despite four attempts on the same possession, including one by Bryant.
Lowry scored for Memphis, then Vujacic hit another 3-pointer to draw the Lakers within 111-109 with 50 seconds left.
Lamar Odom missed a 3-pointer after Bryant, tied up in the lane, fed him on the right baseline. Ronny Turiaf fouled Lowry, who made both for a 113-109 lead.
Turiaf scored inside to get the Lakers back within two after Odom and Vujacic missed. Gay got fouled and made the second of two for a 114-111 lead. Luke Walton inbounded the ball on the Lakers' final play, but he turned it over and Milicic got the steal as time expired.
Bryant notched 47 points through the first three quarters. He scored the Lakers' first seven points, including his seventh and eighth 3-pointers, for a 61-56 lead. The Grizzlies tied it at 63 before a basket by Derek Fisher, a Bryant dunk and his ninth 3-pointer, gave the Lakers their largest lead, 70-63.