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 Pitching with an extra day's rest after his start Sunday was scratched because of rainy conditions, Zambrano (6-1) allowed six hits and three runs in seven innings and also chipped in with his bat.
He doubled to start the Cubs' six-run outburst against Randy Wolf (2-3) and added a single in the sixth when Chicago tacked on five more runs.
The Cubs' first eight batters reached in the fifth on six hits and two walks. Wolf didn't retire a batter in the inning and in four-plus innings, he gave up eight hits, seven runs and five walks. San Diego pitchers issued nine walks and surrendered 13 hits on a cold night at Wrigley Field where the game-time temperature was only 41 degrees.
Jody Gerut's first homer in nearly three years gave the Padres a 2-1 lead in the top of the fifth, but the Cubs quickly responded.
Zambrano drove a ball off the wall in right-center for a leadoff double and Soriano followed with a drive to left-center that just cleared the fence for his fourth homer, putting Chicago up 3-2.
Ryan Theriot walked, Derrek Lee singled and Aramis Ramirez had an RBI single before Kosuke Fukudome worked a walk to load the bases. Geovany Soto's two-run single through the middle made it 6-2 and finished Wolf. Mark DeRosa then greeted reliever Sean Henn with an RBI single.
In the sixth, the Cubs batted around again. They loaded the bases for the third time in the game on Soriano's double and walks to Theriot and Ramirez before Fukudome drew his third walk of the game to force in a run.
It got worse for the Padres, who have the worst record in the majors at 14-25.
When DeRosa hit a grounder to third baseman Kevin Kouzmanoff, he tried to race to the bag for a force, but Ramirez beat him there. Kouzmanoff then threw wildly to first for an error and three runs ended up scoring on the play as the Cubs went up 11-2. Reed Johnson later added an RBI single.
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Lee's double into the right-field corner scored Theriot, who singled, in the first put the Cubs ahead 1-0. Tadahito Iguchi hit an RBI single in the third to tie it.
Notes: Gerut's last homer came on May 24, 2005, against the Twins while he was playing for the Indians. He wasn't in the majors the last two years. ... Padres C Michael Barrett, bothered by a sprained right elbow ligament, threw before the game and could go on a rehab assignment soon. ... Padres LF Scott Hairston fell over the Cubs' bullpen mound chasing Fukudome's foul fly in the sixth, but wasn't hurt. ... Edgar Gonzalez, just called up from Triple-A, had an RBI single in the seventh for his first major league hit. He is the brother of Padres' first baseman Adrian Gonzalez. ... Former Cubs' pitcher Mark Prior, now with the Padres, had a setback in his rehab from shoulder surgery in April 2007. When he felt discomfort in his shoulder at extended spring training in Arizona, he was sent back to San Diego for an MRI, manager Bud Black said. Prior might visit Dr. James Andrews, who performed the surgery, to be checked out.
[Associated Press; By RICK GANO]
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