Adenhart (1-0) allowed four runs and nine hits in 5 2-3 innings, walking three and striking out one. It was the third start for the 21-year-old right-hander, who has given up 12 earned runs, 18 hits and 13 walks over 12 innings while filling in John Lackey.
Lackey, who won 18 games last season for the defending AL West champions, is expected to make his season debut Wednesday night after being sidelined since March 21 with a strained right triceps.
Jermaine Dye had four hits for the White Sox, who scored two runs in the eighth against Chris Bootcheck and one in the ninth against Scot Shields before Francisco Rodriguez got the final two outs for his major league-leading 15th save.
Mark Buehrle (1-5) gave up eight runs and 10 hits in 5 2-3 innings with six strikeouts. The left-hander has allowed 14 earned runs over 11 1-3 innings in his last two starts, after a 2-0 loss at Toronto in which he gave up a pair of unearned runs through eight innings. He is 0-5 with a 5.26 ERA in his last six outings.
Buehrle is 1-5 with a 4.76 ERA lifetime against the Angels, and is winless in his last 12 regular-season starts against them since pitching a four-hitter at Anaheim on Aug. 8, 2001.
Trailing 4-2, the Angels pulled ahead 6-4 in the fifth on Guerrero's three-run homer and Garret Anderson's RBI triple, one of his three hits. Rookie Sean Rodriguez and Gary Matthews Jr. opened the inning with infield hits before Guerrero drove a 1-0 pitch to left-center for his fourth homer and first since April 25. Robb Quinlan also reached on an infield hit and scored on Anderson's drive to the wall in right-center.
Chicago third baseman Joe Crede committed a two-base throwing error on Matthews' two-out grounder in the sixth, leading to four unearned runs and a 10-4 Angels lead. Erick Aybar chased Buehrle with an RBI double, Guerrero followed with an RBI single against Ehren Wasserman, and Casey Kotchman added a two-run single against Boone Logan.
The White Sox grabbed a short-lived 3-0 lead in the second with a bases-loaded infield hit up the middle by Crede and a broken-bat bloop single to center field by Juan Uribe that drove in two runs.
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The Angels responded with two in the bottom half on Mike Napoli's sacrifice fly and a two-out RBI single by Matthews, who entered the game in a 5-for-47 rut.
Crede's run-scoring single to center in the fourth increased Chicago's lead to 4-2.
Before the game, Angels manager Mike Scioscia presented White Sox shortstop Orlando Cabrera with the Gold Glove Award he earned last season with the Halos in a brief ceremony at home plate. It was Cabrera's second Gold Glove, the other coming in 1991 with the Montreal Expos.
Notes: Cabrera played three seasons with the Angels before they traded him to Chicago for RHP Jon Garland in November. Cabrera is batting .230 with a homer and six RBIs in 143 at-bats. Garland is 4-3 with a 4.30 ERA in eight starts. ... Angels RHP Dustin Moseley, who gave up Jim Thome's 500th career homer on Sept. 16 at Chicago, gave up three hits and no runs over 3 2-3 innings while striking out six in a 60-pitch rehab start with Class-A Rancho Cucamonga. He went on the disabled list May 4 with tightness in his forearm.
[Associated Press; By CHRIS JENKINS]
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