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Backed by three RBIs each from Soriano and Soto, Lilly (4-4) allowed six hits and four runs in six innings. After striking out 10 against Arizona in his previous start, he fanned eight in the first four innings.
Lilly has thrown consecutive double-digit strikeout games for the first time in his big league career. He left after throwing 102 pitches on a 46-degree night at Wrigley Field.
Cubs pitchers combined to strike out 15 against the Padres, whose 308 strikeouts are second in the major leagues behind Florida's 326.
Soriano hit his second leadoff homer in as many nights and also had a key two-run single in the second inning for a 3-0 lead after a wild pitch by Jake Peavy on a third strike to Lilly moved up the runners.
Peavy (4-3) needed 87 pitches to make it through four innings. He gave up four runs and seven hits, struck out eight and walked two.
Soto's RBI single in the third made it 4-0, but San Diego closed within a run in the fifth on Tadahito Iguchi's two-run single and Lilly's run-scoring wild pitch.
Soto's seventh homer, a two-run drive off Wilfredo Ledezma, put Chicago up 6-3 in the fifth. Khalil Greene's sacrifice fly cut the margin, but Aramis Ramirez had an RBI double in the sixth and Johnson a run-scoring double an inning later off Bryan Corney to make it 8-4.
Iguchi hit a bases-loaded single off Kerry Wood with two outs in the ninth before Brian Giles flied out.
Notes: It was Peavy's shortest outing since going four innings against Arizona last Sept. 5. ... Soriano has 46 career leadoff homers, third in major league history behind Rickey Henderson (81) and Craig Biggio (53). He has homered in three straight games. ... Peavy made a nice diving catch of Soriano's pop in the fourth. ... Lilly has 12 double-digit strikeout games overall.
[Associated Press; By RICK GANO]
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