The elevated lead levels were not considered dangerous, but North Dakota says pregnant women and children younger than 6 should avoid eating venison harvested using lead bullets.
Those groups are considered most at risk from lead poisoning, which can cause learning problems and convulsions, and in severe cases can lead to brain damage and death.
The study, conducted by the federal Centers for Disease Control and Prevention and the state health department, is the first to connect lead traces in game with higher lead levels in the blood of game eaters, said Dr. Stephen Pickard, a CDC epidemiolgist who works with the state health department.
A separate study by Minnesota's Department of Natural Resources previously found that fragments from lead bullets spread as far as 18 inches away from the wound.
"Nobody was in trouble from the lead levels," Pickard said. However, "the effect was small but large enough to be a concern," he said.
Pickard said the study found "the more recent the consumption of wild game harvested with lead bullets, the higher the level of lead in the blood."
Officials in North Dakota and other states have warned about eating venison killed with lead ammunition since the spring, when a physician conducting tests using a CT scanner found lead in samples of donated deer meat.
The findings led North Dakota's health department to order food pantries to throw out donated venison. Some groups that organize venison donations have called such actions premature and unsupported by science.
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