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Wellemeyer, a 13-game winner in his first full year as a starter, was 1-1 with a 7.00 ERA in six spring starts. He was 3-0 with a 3.45 ERA last year against the Pirates.
McLouth homered in the sixth off Brad Thompson after Sanchez's leadoff double.
Notes: Pujols became only the third Cardinals player in the last 55 years to reach base four times in each of the first two games, joining Ted Sizemore (1974) and Geronimo Pena (1993). ... Pujols is 11-for-25 against Duke. ... Rick Ankiel reached on a strikeout-wild pitch in the fifth when Doumit, the Pirates' catcher, apparently got crossed up and was stunned by a fastball to the chest protector. ... Ryan Ludwick singled in the fourth and has hit in 13 straight games dating to last season.
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