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Ludwick had an RBI single off Wandy Rodriguez (0-1) and Chris Duncan had a run-scoring groundout in the fourth to put the Cardinals ahead 2-0. Greene's two-out RBI single made it 3-0 in the fifth.
Rodriguez had a 1.11 ERA against the Cardinals last year in four starts, although he was 1-2.
Notes: Matsui and Bourn have hit in all six games to start the season. ... Rick Ankiel, 0-for-9 against Rodriguez, was the odd man out in the Cardinals' four-man outfield rotation. ... The Cardinals swept the Astros for the first time since taking three in a row from July 15-17, 2005, in St. Louis.
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