Treasury Secretary Timothy Geithner and other top officials are close to finishing a plan to overhaul the government's $700 billion financial rescue fund. Some investors in recent days have been worried that the government's latest revisions to its lifeline for banks would involve nationalizing many banks.
Speaking generally about the banking industry, Lewis reiterated the strength of his Charlotte, N.C.-based company, saying that BofA would not need additional federal funding and still believes its acquisition of brokerage Merrill Lynch & Co. was the right move.
"It's been painful ... I am still as convinced as ever that strategically this make sense," Lewis said in the CNBC interview.
The interview was Lewis' latest effort to convince employees and investors that he and his management team can lead the bank out of its current crisis.
Earlier in the week Lewis spent almost a million dollars buying shares of his struggling bank and posted a memo to employees that said the bank's board "unanimously endorsed our business model, strategic direction and the team," at its regular meeting on Jan. 28.
Bank of America shares rose $1.29, or 26.7 percent, to close at $6.13 Friday, after falling to a 25-year low
- or $3.77 - in trading Thursday afternoon.
"Investors believe that this bank is about to fail and be nationalized by the United States government," wrote Ladenburg Thalmann analyst Richard Bove in a research note late Thursday.
He added those fears "make no sense whatsoever," and he rates Bank of America's shares a "strong buy."
Lewis purchased 200,000 Bank of America shares for $958,340 on Wednesday, according to a filing with the Securities and Exchange Commission on Thursday. It's the second time in recent weeks that Lewis has pumped his own money into the bank. Two weeks ago, he bought 200,000 shares for $1.2 million.
The bank's shares have been pummeled in recent days following the disclosure of the bank's first quarterly loss in 17 years and mounting concerns about its recent Merrill Lynch acquisition.
Last week, Lewis went before his directors in Charlotte for "the longest board meeting in anyone's memory," he told employees in the memo issued Monday.
Some analysts said Lewis' job might be on the line, but lead director O. Temple Sloan Jr. later issued a statement of support for the bank's management team.
In the memo, Lewis called the company's performance in January "encouraging."