"It's a great thing knowing that I'll be here for hopefully the next five years," the 29-year-old said. "My wife is from Boston and her family's from here and that's a major factor in us staying here."
Youkilis gets a $1 million signing bonus, $6 million this year, $9,125,000 in 2010 and $12 million in each of the following two seasons. Boston has a $13 million option for 2013 with a $1 million buyout.
He hit .312 with 29 homers and 115 RBIs last season, but his most impressive work might have been in the field. The five-year veteran made just four errors in 125 games at first base, where he won a Gold Glove in 2007, then switched to third when Mike Lowell was injured.
Youkilis holds the major league record of 238 straight games at first base without an error, a streak that ended last June.
He finished third in AL MVP voting in 2008, behind Red Sox second baseman Dustin Pedroia and Minnesota first baseman Justin Morneau.
Youkilis is a career .289 hitter with 66 homers and 314 RBI. His .997 career fielding percentage at first base is tops in Red Sox history.
"Kevin has been a mainstay for us and a big part of our major league club through a lot of successful seasons and a big part of our future and we solidified that with this move today," general manager Theo Epstein said.