Takashi Saito (2-0) got the only batter he faced, Jimmy Rollins, to bounce into a double play to end the 12th. Daniel Bard pitched a scoreless 13th for his first save. He hit two batters to bring the tying run to the plate before fanning Shane Victorino to end it.
Jason Bay and pinch-hitter Julio Lugo started Boston's winning rally with consecutive one-out singles off Kyle Kendrick (0-1). After Kendrick walked Jason Varitek to load the bases, Ellsbury lined a single to right. Nick Green followed with a sacrifice fly and Mike Lowell added an RBI single to make it 5-2.
With Jonathan Papelbon unavailable after saving consecutive wins against the New York Yankees the last two nights, the Red Sox turned to Ramirez to protect a 2-1 lead. Ramirez struck out Jayson Werth before Howard connected, sending a long drive to the seats in right for his 19th homer.
Kendrick was called up from Triple-A earlier in the day to replace reliever Scott Eyre, who went on the disabled list with a calf injury. Kendrick won 21 games as a starter over the last two years, but lost a four-man competition for the No. 5 starter's job in spring training. He unraveled after pitching a perfect inning.
Ramirez's blown save spoiled a brilliant outing by Jon Lester, who had 11 strikeouts in seven innings. Lester allowed one run and two hits and retired 18 of the last 19 batters he faced.
J.D. Drew and Kevin Youkilis homered off Phillies starter Joe Blanton, who gave up two runs and five hits in seven innings.
Lester seems to have completely regained his form from last year when he won 16 games, threw a no-hitter on May 19 against Kansas City and was the club's most reliable postseason pitcher.
Lester allowed 11 runs in his first two starts and 13 in consecutive starts last month. Since then, the left-hander has given up one run four times in five starts. In his last outing, Lester was perfect for 6 1-3 innings before finishing with a two-hit complete game in an 8-1 win over Texas.
Drew and Youkilis hit opposite-field homers an inning apart to give the Red Sox a 2-1 lead. Drew was booed each time he came up because Philadelphia fans still can't forget that he refused to sign with the Phillies after being selected with the second overall pick in the 1997 amateur draft.