David Weathers gave up three runs in the eighth, including Tyler Greene's first career homer
- the first runs off the reliever in 11 appearances this season. Francisco Cordero pitched the ninth, remaining perfect in his nine save chances.
Jerry Hairston Jr. doubled home a run in the first inning off Joel Pineiro (4-2) and singled home another in the second, helping the Reds pull out to a 5-0 lead.
The Reds won their second game in a row without two stalwarts. First baseman Joey Votto, who leads the team in batting at .378, and Gold Glove second baseman Brandon Phillips were sidelined again with the flu. Cincinnati also is missing shortstop Alex Gonzalez, sidelined by pulled muscles in his left side.
The question was whether Cueto could handle the NL Central-leading Cardinals, who at 19-11 are off to their best start since 1982, when they won the World Series. As a rookie last season, Cueto lost both of his starts against St. Louis, getting pounded for 13 runs in less than seven innings.
This time, they barely touched him.
Cueto was coming off the best performance of his career, allowing only four singles in eight shutout innings of a 5-0 victory in Pittsburgh on Sunday. His streak of scoreless innings reached 15 over the last three starts before Joe Thurston grounded into a run-scoring double play in the seventh.