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The back-to-back homers to start were the first by the Cubs since April 27, 2000 at Houston and the first ever allowed by San Diego, according to the Elias Sports Bureau.
Soto, who raised his average from .175 to .193, then singled in Milton Bradley to give Chicago a 3-2 lead and made it 5-2 with that homer in the third.
Besides dropping the game, the Padres lost shortstop Luis Rodriguez to a sprained left ankle. He was injured rounding first following a single in the seventh and was lifted for a pinch runner.
Notes: Cubs ace Carlos Zambrano threw a bullpen session on Wednesday and remained on track to make a rehab start this weekend. Zambrano went on the 15-day disabled list on May 4, a day after he strained his left hamstring trying to beat out a bunt. He is scheduled to pitch Saturday or Sunday in Clearwater, Fla., before starting against San Diego on May 22. ... 3B Aramis Ramirez said he's still feeling pain in his dislocated left shoulder and isn't sure when he'll return. He was injured on a backhand dive against Milwaukee on May 8 and went on the disabled list the following day. ... Rickey Henderson holds the major league record with 81 leadoff homers.
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