President Barack Obama announced Friday that he has picked the 48-year-old Frieden to lead the public health agency, where he will be faced with some immediate decisions on how to deal with the swine flu outbreak, including whether to produce a vaccine. Frieden also may play a role in health care reform.
The selection reunites Frieden with an agency where he worked as an infectious-disease detective at the beginning of his career.
New York's health commissioner is not usually a household name, but many New Yorkers quickly got to know Frieden after his appointment in 2002, when he began a series of not-so-gentle campaigns to get the city to live healthier.
In 2003 he pushed through a ban on smoking in almost all workplaces, a rule that instantly transformed nightlife in the big city.
Big increases in cigarette taxes followed, aimed at making the habit so expensive people would give it up. This spring the average price of a pack in New York topped $9.
Smokers were outraged, but the backlash was short-lived and the city claims the effort is working: About 350,000 fewer adult New Yorkers smoke now than in 2002.
"There is probably nothing any person will ever do to save as many lives as that one act of our legislature getting together here in the city and passing the smoking ban, and Tom deserves the credit," Mayor Michael Bloomberg said Friday.
Frieden followed that up with a pair of new rules aimed at obesity.
One banned restaurants from cooking with artificial trans fats, substitutes for natural fats such as lard. Fast-food companies all over the country wound up altering their recipes. Even McDonald's had to change the way it cooked french fries.
The city also began requiring thousands of chain restaurants to post the calorie content of their foods on the menu, saying diners deserve to know before they order that a blooming onion can have four times the caloric punch of a Whopper.
Critics complained that he was fostering a nanny state and infringing on privacy rights.
"This is like no-fun city," one smoker complained.
Frieden is unapologetic. Illnesses such as heart disease, he said, are now leading killers, cost taxpayers billions of dollars, and should be treated with the same urgency as an outbreak of a contagious illness like tuberculosis.
In a 2004 editorial in the American Journal of Public Health, he chided most public health agencies for being "asleep at the switch" on chronic disease.
"Local health departments generally do a good job of monitoring and controlling conditions that killed people in the United States 100 years ago," while doing little about modern-day threats like diabetes, he wrote.