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About the only bright spot for the Buffaloes was sophomore tailback Darrell Scott. After carrying the ball only once in the opener for 1 yard, he ran for 85 yards on 12 rushes -- all in the first half.
Cody Hawkins completed 30 of 64 passes for 356 yards and four touchdowns -- but also threw three interceptions.
Hawkins was shaken up after diving in for a meaningless late TD, when he and Toledo's Archie Donald had a helmet-to-helmet collision at the goal line. The quarterback's condition wasn't available after the game.
Toledo recovered the onside kick and knelt the ball to end the game just before 1 a.m.
Rockets running back DaJuane Collins ran for 162 yards and a touchdown on 20 carries.
Opelt finished with 319 yards passing a week after throwing for 423 yards in a loss at Purdue. He completed 15 of 23 and ran for 109 yards.
His 27-yard run with 36 seconds left in the first half put the Rockets up 23-3, and he opened the second half with a 26-yard TD pass to Kenny Stafford.
The Rockets are 3-0 at home against the Big 12, having beaten Kansas in 2006 and Iowa State in '07.
Toledo, which plays Ohio State next week in Cleveland, has seven victories over teams from BCS conferences in the last nine seasons, including last year's win at Michigan.
It's the first time the Buffaloes have lost to a Mid-American Conference school. They beat Kent State in 1977 and Miami in 2007.
[Associated Press;
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