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49ers 20, Cardinals 16
At Glendale, Ariz., Shaun Hill directed a 15-play, 80-yard drive for the winning touchdown on a 3-yard pass to Frank Gore, and San Francisco spoiled the season debut of defending NFC champion Arizona.
The Cardinals rallied from 10 points down to go up 16-13 on Neil Rackers' 44-yard field goal with 14:52 to play. But the 49ers regained control with the drive that used up nearly half of the final quarter.
It was the Cardinals' first loss to an NFC West foe in two seasons.
Seahawks 28, Rams 0
At Seattle, Matt Hasselbeck played his first game since Thanksgiving Day and overcame two early interceptions to connect with John Carlson for two touchdowns.
Hasselbeck finished 25 of 36 for 279 yards as Seattle beat its division rival for the ninth consecutive time with its biggest win to begin a season since a 38-0 victory over Philadelphia in 1998.
The Rams, under new coach Steve Spagnuolo, gained just 247 yards and were doomed by 10 penalties.
Ravens 38, Chiefs 24
At Baltimore, Joe Flacco went 26 for 43 for 307 yards and three touchdowns, all career highs, and the Ravens ruined the head coaching debut of Kansas City's Todd Haley.
The Ravens amassed a franchise-record 501 yards, yet needed a 31-yard touchdown catch by Mark Clayton with 2:06 left to break a tie. Willis McGahee scored from the 1 with 31 seconds remaining to clinch it.
The Chiefs kept it close despite playing without quarterback Matt Cassel, whose sprained left knee didn't heal enough to enable him to make his Kansas City debut.
Cowboys 34, Buccaneers 21
At Tampa, Fla., Tony Romo threw for 353 yards and three long touchdowns, spoiling the Buccaneers' debut under coach Raheem Morris.
Miles Austin avoided two tacklers on the sideline to score on a 42-yard reception just before halftime. Roy Williams streaked through a mistake-prone secondary on a 66-yard TD play early in the third quarter.
Tampa Bay's Cadillac Williams, back after having surgery twice in 15 months, finished with 97 yards on 13 carries and scored a TD.
Falcons 19, Dolphins 7
At Atlanta, Falcons tight end Tony Gonzalez hauled in a touchdown pass and became the 21st player in NFL history with 11,000 yards receiving.
Linebacker Mike Peterson forced a fumble with a vicious hit and picked off a pass for the Falcons. The matchup between the two most surprising teams of 2008 wasn't much of a game. The Falcons' defense came up with four turnovers and thoroughly shut down a team that won the AFC East after going 1-15 two years ago.
Matt Ryan threw a pair of touchdown passes for the Falcons, and Gonzalez hauled in five passes for a team-high 73 yards, including a 20-yard touchdown after Peterson's pick.
Colts 14, Jaguars 12
At Indianapolis, Peyton Manning threw for one touchdown, Joseph Addai ran for another and the Colts' defense stopped Jacksonville twice in the fourth quarter.
Though Manning tied John Unitas' franchise record for career wins with 118, it was hardly a thing of beauty. Manning lost receiver Anthony Gonzalez late in the first quarter with a right knee injury. Reggie Wayne finished with 10 catches for 162 yards and a TD and Colts coach Jim Caldwell won his NFL head coaching debut.
Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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