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The prettiest score came when Manning lofted a pass down the sideline into the outstretched arms of Garcon on a 53-yard scoring play that made it 21-3 with 1:52 to go in the half.
Warner drove the Cardinals (1-2) to the Indianapolis 1-yard line in the final seconds of the half. He threw to Steve Breaston at the goal line but Melvin Bullitt didn't allow the receiver into the end zone.
On the next play, Warner threw under pressure toward Larry Fitzgerald in the end zone. Tim Jennings deflected the ball in the air and Bethea intercepted.
Arizona took the second half kickoff and went 73 yards in eight plays, with Warner throwing 10 yards to Anquan Boldin for the touchdown to cut it to 21-10 with 10:50 to play in the third.
But a 72-yard pass play from Manning to rookie Donald Brown set up the 3-yard TD toss to Addai to boost the lead to 28-10 with 2:26 left in the quarter.
Colts defensive end Dwight Freeney, who had harassed Warner all night, limped off the field at the end of the third quarter with a right leg injury and did not return. Indianapolis was without two defensive starters -- middle linebacker Gary Brackett and cornerback Kelvin Hayden.
Arizona, 8-2 at home last season, fell to 0-2 there this season, with echoes of boos through what was left of the crowd as Warner was sacked for a 28-yard loss on fourth down with about 6 1/2 minutes to play.
Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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