Seattle (1-2), playing without seven injured starters, drove to the Bears 29 with 30 seconds left. But Seneca Wallace, starting because quarterback Matt Hasselbeck was out with a broken rib, threw high and incomplete to Julius Jones on fourth-and-2 to seal the win for the Bears (2-1).
Cutler finished 21 of 27 for 247 yards and three touchdowns, with one interception.
"Any time you can get Devin Hester one-on-one, it works," a confident Cutler said on the field seconds after the game ended.
Cutler completed more than 70 percent of his throws last week against the Super Bowl champion Pittsburgh Steelers
-- a strong response to the career-high four interceptions he threw in a loss on opening night at Green Bay.
Chicago was up 17-16 with 8 minutes left when Seahawks rookie linebacker Aaron Curry sped into Cutler's passing arm and knocked the ball loose. Cory Redding recovered the fumble at the Bears 39.
Olindo Mare, who was just 4 of 6 on field goals, converted the turnover into a 46-yard field goal. The Seahawks led 19-17 with 5:17 remaining.
The Bears answered by driving to the Seattle 36 by the 2-minute warning. Matt Forte was bent back awkwardly at the end of an 11-yard run. Adrian Peterson replaced him and ran twice for 12 yards.
Then Hester ran a slant route inside Travis Fisher, who was playing because Seattle was without starting cornerbacks Marcus Trufant and Josh Wilson. Safety Deon Grant tried to level Hester but nailed Fisher instead. With both Seahawks on the turf, Hester trotted in for the go-ahead score.
Seattle's T.J. Houshmandzadeh lost a fumble after a catch on the second play of the third quarter. Danieal Manning knocked the ball out from behind, and Adewale Ogunleye recovered at the Seahawks 42. Cutler then found Johnny Knox on third down over the middle. The rookie juked Curry and dived in for a 7-yard touchdown. Chicago had its first lead, 14-13.
Seattle would have answered by taking the lead if oft-injured Deion Branch, making his season debut, hadn't allowed a third-down pass to go through his hands at the Bears 11, or if Mare hadn't missed his second field goal of the day on the next play.
On Seattle's next offensive play, Wallace -- who set career highs with 26 completions in 44 attempts and 261 yards
-- threw a slingshot-like toss across his body while pressured in his end zone. Lance Briggs made a diving interception at the Seahawks 14.
Robbie Gould turned that into a 37-yard field goal and the Bears led 17-13.