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Porcello (4-10) was tagged for seven runs and eight hits in 4 1-3 innings and was chased as the White Sox took a 7-1 lead in the fifth.
"When I wanted to throw certain pitches for strikes, especially in big situations, I would either throw a ball or miss out over the plate," Porcello said.
Detroit fell below .500 and dropped eight games behind Chicago. Austin Jackson had three hits for the Tigers. Buehrle walked one and struck out one in 7 2-3 innings.
"It could have been an ugly game," he said. "I didn't have good command and fell behind a lot early."
Scott Linebrink went the rest of the way.
Chicago took a 4-0 lead in the third. Pierre's double brought in the first run, Omar Vizquel hit a sacrifice fly, and Rios and Paul Konerko followed with consecutive RBI singles.
Jackson had an RBI single in the third.
Beckham's sacrifice fly in the fifth made it 5-1. Pierre homered in the fifth and one out later Rios hit his 17th homer.
The White Sox added four more runs in the seventh. Mark Kotsay and Beckham hit RBI singles and Ramirez had a two-run double. Viciedo hit his third home run in the eighth.
Jeff Frazier had an RBI single for the Tigers in the eighth.
NOTES: Vizquel was 3 for 3 in the nightcap. With his 2,758th hit, he moved past Vada Pinson into sole possession of 49th place on the career list. ... Damon was Detroit's DH for both games of the doubleheader after missing three games with a sore back. ... Konerko's home run was estimated at 424 feet. ... Jackson has 122 hits, which leads AL rookies and is the most by a Tigers' rookie since Milt Cuyler had 122 in 1991.
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