The 20-year-old from Hawaii had the second ace of her professional career Thursday on the way to a 7-under 65 and a three-stroke lead after the first round at the CN Canadian Women's Open.
Wie raised her hands in the air and got a high-five from playing partner Cristie Kerr after the ace on the 190-yard, par-3 11th hole at the St. Charles Country Club.
After her first hole-in-one, in her rookie season at last year's McDonald's LPGA Championship, the 6-foot-tall Wie did a dance.
"I did a little shimmy after I made it in at McDonald's and it got replayed one too many times and (TV sportscaster) Scott (Oake) made fun of it a little bit too much," Wie said. "So (I) just decided against it. I really wanted to, but I didn't. But it was pretty crazy."
The youngest player to qualify for the U.S. Amateur Championship at age 10, Wie said she's had eight aces in her career, but this was the only one in a tournament that she actually saw roll into the cup.
Sarah Kemp of Australia was three strokes behind Wie after her morning-round 68, while defending champion Suzann Pettersen of Norway was alone in third place at 69.
Rookie Ilhee Lee of South Korea initially had a score of 69 after her early round, but it was later corrected to 70
-- a mark shared with seven others.
Seema Sadekar of Toronto was the low Canadian with a 72, two strokes ahead of Sue Kim of Langley, B.C. Kim is playing with a heavy heart after her father died in a car accident earlier this month.
Wie delivered a second spectacular shot, on No. 17, when she holed out from a greenside bunker for a birdie.
"I just really thought I could make it, and I went up there, really thought about it, just trusted it, and kind of did what I thought it would do," Wie said.
The Canadian Open is Wie's 15th event this season. She's had three Top-10 finishes, with the best a third at the Tres Marias Championship in May. Her only career victory came at last November's Lorena Ochoa Invitational.
Kemp overcame blustery winds during the day to tally six birdies and two bogeys on the par-72, 6,572-yard course.
"My putter, I think, was the 4-under today," said Kemp, 25, who's in her third season on the Tour. "I holed some really good putts and I just kept it in play."