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Maholm has been 3-0 with a 2.25 ERA in three starts against the Cubs this season.
Zambrano's two-run home run in the fifth gave the Cubs a 11-0 lead. It was Zambrano's 21st career home run, extending the club record for most home runs as a pitcher. It was his first home run since Aug. 25, 2009.
Ramirez drove in two more runs on a double down the left-field line.
Zambrano was helped by a great throw from right fielder Tyler Colvin in the fourth inning. Garrett Jones led off the inning with a line drive off the right field wall. Colvin played the ball off the wall and threw to second to get Jones attempting to extend the hit to a double.
NOTES: The Cubs honored 2010 Hall of Fame inductee Andre Dawson in a pregame ceremony. ... Castro has the fifth best batting average in the NL. ... The Cubs started a nine-game, 10-day homestand.
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