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Manning made the Titans pay with a slant to Pierre Garcon, who shook off Jason McCourty and Hope while safety Michael Griffin whiffed as the receiver slipped up the right sideline for a 43-yard play. Adam Vinatieri ended the drive with his third field goal, a 47-yarder that made it 30-21 with 2:55 left.
"Peyton was Peyton. I'm sure he felt good about his performance, and certainly we did as well," Colts coach Jim Caldwell said.
Injury-riddled Indianapolis finished the game with just five healthy offensive linemen, making the win even more precious.
"It's tough to do in this league," Caldwell said. "It feels good, particularly our guys had to fight through some injuries."
The Titans used up every second trying to rally. Collins found Scaife again for a 2-yard TD pass as time expired.
"It was good," Fisher said. "It just happened too late."
Collins finished with 244 yards passing and three TDs, giving him 200 for his career.
But it was Manning who really got back on track, putting the Colts up 21-7 at halftime with TD passes of 1 and 19 yards to Garcon after tossing a career-worst 11 interceptions during Indianapolis' slide. The first TD pass was his 25th on the year, becoming the first quarterback to reach the mark in 13 consecutive seasons.
Javarris James also scored on a 1-yard plunge, his NFL rookie-best sixth rushing touchdown of the season.
Tennessee started Kenny Britt for the first time since he strained his right hamstring on Halloween, sitting Randy Moss. Collins connected with Britt twice for 23 yards. But Collins tossed a screen to Britt to open the second quarter, and Dwight Freeney hit him, knocking the ball loose. Tyjuan Hagler recovered the ball at the sideline for the Colts.
Moss finished the game without a reception.
NOTES: The Colts improved to 12-5 against the Titans with Manning. ... Colts LT Charlie Johnson hurt a shoulder and backup guard Jamey Richards also hurt a hip. They did not play in the second half. ... Titans DT Jovan Haye had a stinger in the first half. ... Fisher tied Steve Owen for eighth all-time with 270 games coached with one team. Owen coached with the Giants between 1930 and 1953. ... Collins became the 31st player in NFL history with 200 TD passes.
[Associated Press;
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