But UTEP (12-5, 3-1) built a second-half lead that reached seven and held on to end the overall streak and also Memphis' regular-season C-USA winning streak at 52 games.
Kentucky also won 64 consecutive conference games from 1945-50.
Memphis had a chance on a late possession to tie the game, but turned the ball over with 4.3 seconds left. Christian Polk, who finished with 17 points for the Miners, hit a pair of free throws with 3.5 seconds left. Derrick Caracter scored 14 points for the Miners.
Elliot Williams led Memphis with 23 points, while Wesley Witherspoon added 12 for the Tigers (13-5, 3-1).
UTEP coach Tony Barbee was an assistant coach under former Memphis coach John Calipari when the streak started.
UTEP took the lead for good with 9:40 left when Polk connected on a 3-pointer from the top of the key. From there, Memphis got within a point
-- 65-64 with 3:30 left on a pair of free throws by Witherspoon, but couldn't catch the Miners.
The teams exchanged leads early in the first half, neither building an advantage of more than four points until Memphis created a slight lead with a trio of baskets, including 3-pointers by Doneal Mack and Willie Kemp.
That run allowed Memphis to lead 34-31 at halftime, despite a pair of 3-pointers from Polk in the final minutes.
Williams carried the Tigers in the half with 12 points. Caracter gave UTEP an inside presence early, and Polk provided a closing offensive punch.
Memphis' lead was built behind shooting 5 of 10 from outside the arc. But UTEP countered with 10 points off Memphis turnovers and outrebounding the Tigers 19-13.
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