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Trailing 1-0, Ramirez tied the game in the third inning with a leadoff home run. It was his sixth of the season.
The White Sox scored a season-high seven runs and had eight hits in the fourth inning.
Castro and Pierre had RBI singles in the eighth inning and Vizquel added a two-run double.
NOTES: Tigers RF Magglio Ordonez was out of the lineup for the second straight game with soreness in his left side. ... Gordon Beckham ended a streak of 112 at-bats without an extra-base hit with a double.
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