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After Joyce walked with two outs in the ninth, Upton hit a drive that was caught at the center field fence.
"The ball ran out of gas at the last second," Arizona center fielder Chris Young said. "When he swung the bat and made contact, I thought he was the hero."
Parra hit his second homer of the season off Wade Davis (5-9) to put Arizona up 2-0. Davis gave up two runs and four hits over 7 1-3 innings, and is 0-5 in five starts during June.
The Diamondbacks have only three wins in their last 19 road games.
"You come into this place against a good team and get a series win, it's time to get out of town and go on to the next city," Diamondbacks manager A.J. Hinch said.
Carlos Pena had an RBI double in the sixth to make it 2-1.
Ben Zobrist hit a two-out liner with Longoria on third in the bottom of the fourth that hit Lopez on the left forearm. Lopez recovered to threw Zobrist out at first.
In the first meeting between brothers, Arizona's Justin Upton got the better of B.J. Justin Upton went 5 for 9 with a homer in the series, while B.J. was hitless in nine at-bats.
NOTES: Jackson, who threw a 149 pitch and walked eight Friday, will have his next start pushed back from Wednesday to Friday or Saturday. ... Rays LF Carl Crawford (sore left shoulder) was out of the lineup for third straight game, but did pinch run in the eighth.
Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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