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But the Chargers struggled to take control early.
Manning threw a 5-yard TD pass to Jacob Tamme on the Colts' opening possession and the Chargers answered with a 28-yard field goal from Nate Kaeding.
Then things took a nasty turn for the Colts.
When Manning tried to connect with Wayne between three defenders, Burnett made a leaping grab and sprinted into the end zone to make it 10-7.
Stephen Cooper picked off Manning again early in the second quarter, setting up a 33-yard field goal that made it 13-7. Manning brought the Colts back from a 16-7 deficit by throwing a 6-yard TD pass to Blair White with 22 seconds left in the half.
But the Colts never got back in the game.
Kaeding opened the second half with a 30-yard field goal, and then Weddle picked off Manning and returned it 41 yards for a TD to make it 26-14.
Tolbert sealed the win with his 3-yard run with 11:26 left.
"San Diego did a good job," Manning said. "Offensively, we didn't do a real good job. I didn't do a real good job."
[Associated Press;
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