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San Francisco coach Mike Singletary said he went more with Westbrook than rookie Anthony Dixon because of experience and track record.
"He is a pro. When he came in we told him that it is a long year and when your number is going to be called be ready to step up," Singletary said. "He is a bright guy, works hard and plays his role. Tonight, he had to step up and he did."
Smith didn't need to pass much, completing 11 of 23 for 129 yards with one touchdown and an interception.
San Francisco, a team that has not scored more than 24 points in a game all season, led 21-6 at the half. The 49ers hadn't scored that many by halftime in two years.
The Cardinals committed their 27th turnover of the season on their first play from scrimmage when Anderson and Beanie Wells botched a handoff and Aubrayo Franklin recovered for San Francisco. On the next play, Smith threw 38 yards to Michael Crabtree for the touchdown, the receiver making a diving catch in the end zone.
Wells gained a measure of redemption on the next possession. Playing as a wideout to the right, he caught a 43-yard pass from Anderson but a season-long red zone problem continued and Jay Feely's 31-yard field goal made it 7-3.
Ted Ginn Jr. had a kickoff return of 41 yards and a punt return for 42, both leading to San Francisco touchdowns.
The 49ers went 55 yards in 10 plays after the kickoff, Dixon leaping over from the 1-yard line to make it 14-3 with 29 seconds to go in the first.
Shane Andrus, kicking in place of injured Joe Nedney, missed a 47-yard field goal on San Francisco's first possession. He also had a 37-yarder blocked by Dominque Rodgers-Cromartie in the third quarter.
Arizona blew an opportunity late in the first half after Smith's pass bounced off the hands of Vernon Davis and was intercepted by Michael Adams at the San Francisco 42. Anderson threw three incompletions and the Cardinals punted. The boos that had started midway through the first quarter were louder than ever as the teams left the field.
LaRod Stephens-Howling briefly got the fans back in it with an 83-yard kickoff return to start the second half, but it was called back by a holding penalty against Arizona rookie Daryl Washington.
NOTES: The Cardinals have sold out all 50 games since moving to University of Phoenix Stadium. ... San Francisco is 5-2 against Arizona since Whisenhunt became coach in 2007, the only NFC West team with a winning record against the Cardinals in that span. ... The Cardinals were without two defensive starters -- end Calais Campbell (ankle) and cornerback Greg Toler (foot). ... San Francisco lost LB Parys Haralson (ankle) and C David Baas (jaw).
[Associated Press;
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