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Ohio State's defense limited Marshall to 44 yards on the ground and 199 total. Brian Rolle picked off Brian Anderson's pass and returned it 30 yards for a touchdown late in the second quarter.
Anderson, who completed 17 of 28 passes for 135 yards, was harassed most of the night. He had an interception and the Herd also lost two fumbles.
"As good as their front four is, they don't have to bring a lot of people," Anderson said.
Meanwhile, the Buckeyes' offense amassed 529 yards.
The first play was telling for the Thundering Herd.
Andre Booker took the opening kickoff and was hit hard by Dorian Bell and Dominic Clarke. The ball came loose and Nate Oliver recovered at the Marshall 22 for Ohio State.
Four plays later, Posey was open by a mile in the left corner and Pryor hit him for a 4-yard score.
After a punt, the Buckeyes were right back in business.
Pryor hit Posey for a 5-yard gain before Saine raced 40 yards off left tackle, breaking two tackles on the way to the 4. He then took a pitch untouched around right end for another score.
The Buckeyes had run seven plays, taking 2:13, and were up 14-0.
The offense continued to click.
Pryor hooked up with Sanzenbacher on a 65-yard bomb and Saine added a 45-yard scoring run on a quick burst up the middle.
The Buckeyes did have some problems with special teams, but those will get a lot of attention over the next few days.
And so will the Hurricanes.
"It's a big game and if you're not ready to play, they'll hit you right in the mouth," defensive lineman Cameron Heyward said. "But we can't let our emotions get the best of us."
Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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