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The Cubs were shut out for the 10th time this season.
Humberto Quintero hit an RBI single in the second and Pence connected in the third for his 23rd homer. Chris Johnson added an RBI single in the fifth and Keppinger drove in a run with a groundout in the sixth.
After being benched the previous two games by Quade, Castro committed an error on Carlos Lee's grounder to shortstop in the first inning. Quade sat Castro for his poor defensive play and not knowing how many outs there were during the seventh inning of Chicago's 18-5 loss to the Mets on Sunday.
NOTES: The Cubs are 26-41 against divisional opponents.
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