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The Giants loaded the bases with none out in the first, but scored just once as Buster Posey hit into a double play that drove in a run. But San Francisco broke loose the next inning, highlighted by Uribe's 21st and 22nd home runs.
Uribe's two-run shot off Dempster cleared the left-field wall and landed on Waveland Avenue for a 3-0 lead. He later hit his fifth career slam, a drive off Diamond into the left-field seats.
In between Uribe's homers, the Giants opened a 6-0 lead on RBI singles from Freddy Sanchez and Posey.
Posey hit a solo homer in the third, his 16th of the season. Cody Ross made it 12-0 when he homered off Marcos Mateo in the sixth.
Pablo Sandoval's RBI single in eighth completed the rout.
NOTES: Sanchez had four hits and Ross had three. ... The 1972 Indians and 1981 Athletics also went 16 straight games of giving up three or fewer runs. ... San Francisco travels to Colorado for a three-game series beginning Friday. ... Cubs leadoff man Jeff Baker was a late scratch because stomach flu.
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