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Buehrle walked leadoff batter Derek Jeter on four pitches in the first and Alex Rodriguez blooped a two-out single that put runners at the corners.
Cano lined a 1-1 pitch into the right-field stands -- not far from where late substitute Brent Lillibridge made two dazzling catches in a row Tuesday night to rob the Yankees of a ninth-inning comeback in a 3-2 loss.
Cano has homered in two straight and four of his last five home games.
"I've been working on staying back. I've been jumping too much and getting caught in between," he said.
Colon wriggled out of a bases-loaded, none-out jam in the second. He gave up three straight one-out singles in the sixth and feigned firing his glove away when Dunn's base hit went through the box and into center field. But he recovered by getting Alex Rios on a flyball and throwing a called third strike past A.J. Pierzynski.
"Colon was amazing," Guillen said. "I had a good opportunity to watch the game (on) TV. It was amazing how that ball had a lot of movement."
NOTES: Girardi said a battery of tests revealed that Hughes has a low-level risk of thoracic outlet syndrome, a circulatory problem. The team will send him to St. Louis to see a specialist, Dr. William Thompson. ... New York 1B Mark Teixeira was lifted for a pinch-hitter in the eighth. He has a sore right shoulder but hopes to play Thursday night. ... Colon hit Carlos Quentin with a pitch in the third, the seventh time Quentin has been plunked this season. No other major league player had more than four going into Wednesday. ... The victory made Girardi the ninth manager to reach 300 regular-season wins with the Yankees. He is 300-207 since taking over before the 2008 season.
[Associated Press;
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