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Clay Hensley (1-4), making his fourth start since joining the rotation from the bullpen, lasted 2 1-3 innings and allowed six runs. His ERA rose from 3.09 to 4.46.
After coming out of the game, Hensley phoned Freese and apologized.
"I didn't have any idea where the ball was going. Hands down, the worst I've ever pitched in my entire career," Hensley said. "It's frustrating, because the lack of control that I had tonight could have seriously hurt somebody."
In the first inning, Hensley walked consecutive batters before Holliday homered.
"We can't give guys free passes -- three or four walks and a couple hit batsmen," Marlins manager Jack McKeon said. "They've got guys like Pujols, (Lance) Berkman and Holliday. We can't put guys on in front of those guys and expect not to get burned."
Florida pulled even with four hits in the bottom of the first, including an RBI double by Infante and a two-run double by Logan Morrison.
Hensley hit Holliday and Freese with pitches in the third. The pitch to Freese was Hensley's last, and Schumaker then hit a two-run double to put the Cardinals up 6-3.
Infante was hurt when Schumaker's grounder deflected off his right hand before rolling into right field.
NOTES: Florida's Wes Helms played 2B for only the second time in his career when he replaced Infante. ... RHP Jake Westbrook, who starts Friday for the Cardinals, is 7-2 in night games this year. ... Florida RHP Anibal Sanchez will seek to snap a career-long slump of nine starts without a win Friday. ... Hensley had not hit a batter previously this year. ... The stadium hosted its third sport in as many nights. The Dolphins practiced there Tuesday, and an international soccer game was played there Wednesday.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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