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Pujols singled in two of his first three at-bats and his one-hop smash that glanced off second baseman Mark Ellis' glove made it 2-1 with none out in the sixth. Holliday bounced a double over the head of third baseman Scott Nelson on the next pitch for a two-run cushion and Freese's two-run single made it 6-1.
Lohse had early success going after hitters, with first-pitch strikes to 11 of the first 12. That stretch was capped by Gonzalez's homer to straightaway center leading off the fourth to tie it at 1, and the Rockies loaded the bases on two walks and Todd Helton's double later in the inning before Cook popped out to shallow right.
Cook allowed a season-worst six runs in 5 2-3 innings and is 0-2 in August while surrendering 12 runs in 16 1-3 innings. He had no regrets about his work against the Cardinals.
"It's very frustrating, but I've got to try to just laugh this one off and realize I know I made the pitches I wanted to make," Cook said. "They were able to just find the holes to get the runs."
Gonzalez is 3 for 19 with two homers during the Rockies' trip.
NOTES: Lohse's last RBI at home was Aug. 16, 2009, against the Padres. He has two RBIs this season to go with a .143 average (7 for 49). ... Holliday is a career .367 hitter (18 for 49) against the Rockies with three homers and seven RBIs. ... Freese is batting .390 (23 for 59) with runners in scoring position. ... Edgmer Escalona worked 2 1-3 scoreless innings of relief for the Rockies, allowing only a walk. ... Helton is batting .435 (10 for 23) against Lohse. ... Jason Hammel (6-11) takes the mound for the Rockies on Saturday against the Cardinals' Jaime Garcia (10-5). ... Lance Berkman has a seven-game hitting streak, going 11 for 25, and has hit in 18 of 20 games since the All-Star break. ... Yadier Molina was 0-for-3 with a sacrifice to end a 14-game hitting streak one shy of his career best.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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