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UCLA narrowed it with quarterback Kevin Prince's flea-flicker to Nelson Rosario for a 37-yard touchdown, but James added a 3-yard scoring run to make it 28-14 before Thomas connected with Daryle Hawkins for a 25-yard TD reception.
UCLA's Tyler Gonzalez kicked a 44-yard field goal to make it 37-17 at halftime.
Prince scored on a 1-yard run early in the third quarter to pull UCLA closer to the Ducks, but James answered with a 5-yard TD dash to make it 42-24.
A Heisman Trophy finalist last season as a sophomore, James fell out of the running for the most part this season because he missed two games with a dislocated right elbow.
There has been speculation all season last season that James may leave for the NFL after this season.
David Paulson caught a 22-yard touchdown pass midway through the third, which put Darron Thomas in front of Danny O'Neil (1991-94) for most passing TDs at Oregon. Thomas has 63.
Rosario pulled down a one-handed, 19-yard touchdown pass from Prince with less than two minutes to play. Rosario finished with six catches for 98 yards.
Prince completed 13 of 26 passes for 164 yards and two touchdowns.
Oregon was stung early in the game when dynamic true freshman De'Anthony Thomas fumbled after a hit by Tevin McDonald. Shaken up on the play, the versatile running back who earlier this week was named the Pac-12's co-freshman of the year on offense did not return.
Oregon coaches said after the game the injury was not serious.
The addition of Colorado and Utah to the Pac-12 paved the way for a league championship game this season. In previous years, the team with the best conference record claimed the title.
While No. 9 USC (10-2, 7-2) finished atop the Pac-12 South, the Trojans are ineligible to play in the postseason because of NCAA sanctions, which put UCLA in the title game.
Because of Neuheisel's dismissal, offensive coordinator Mike Johnson will take over if UCLA is selected to play in a bowl game. The NCAA granted permission to the Bruins to play in a bowl despite their losing record.
The Bruins have reached just one bowl in the past three seasons. Athletic director Dan Guerrero said he wants to reward the Bruins' 18 seniors by going to a bowl even while the program is in upheaval.
Oregon went to the 2010 Rose Bowl in its first season under Kelly, losing to Ohio State. Last season the Ducks went to the BCS championship, where they fell to Auburn.
[Associated Press;
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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