They earned their seventh -- and most improbable -- AFC South title in eight seasons.
"We know what they were up against and how difficult it was and to overcome all that and win the division," owner Jim Irsay said, "it is extra special."
For the Colts (10-6), there were plenty of reasons to celebrate.
They tied Dallas' NFL record of nine consecutive playoff appearances, set from 1975-83.
Manning broke Gene Upshaw's long-standing record for most consecutive starts to open a career (208) and then set a new mark for completions in a season (450), established just a few hours earlier by Drew Brees. The four-time league MVP also threw his 398th and 399th career TD passes, falling one short of joining Brett Favre and Dan Marino as the only members of the 400 club.
Reggie Wayne caught nine passes for 68 yards and one TD, moving past Hall of Famer Raymond Berry into second in franchise history with his 69th career touchdown receiving.
Indy became only the third team since 2000 to lose a Super Bowl and return to the playoffs the following year.
Plus, the Colts did all that despite having 17 players on injured reserve.
The reward: a Saturday night showdown with the New York Jets in a rematch of last year's AFC title game. They also have a chance to host a second straight championship game as the surprise No. 3 seed, thanks to Kansas City's 31-10 loss to Oakland.
"I'll wait until Tuesday to get into that (the Jets)," Manning said. "We just kind of found out what time we're playing and who we're playing and get going on them starting this week."
Yes, the Colts were fortunate.
After losing to Dallas on Dec. 5, they were 6-6 and in serious jeopardy of missing the postseason for the first time since 2001. So coach Jim Caldwell told his players they needed four straight wins to make it back.
They did it, barely, and got a little help along the way.
Moments after Dominic Rhodes lost a fumble and Tennessee ran it back to the Colts 37, Houston's 34-17 victory over Jacksonville went final
-- assuring the Colts of the division crown. But they still needed to win to avoid a possible second-round matchup at New England.
Two plays later, Kerry Collins fumbled the snap and Robert Mathis recovered at the Colts 38. Manning needed only five plays to get the Colts into Vinatieri's range, then waited patiently next to the official as the clock ticked down. He called timeout with three seconds left.
Vinatieri, the best clutch kicker in league history, wasted no time in adding another line to his legacy, raising his arms after the 43-yarder went through.