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Fernando Salas worked the ninth to earn his 13th save and conclude the Cardinals' first sweep on the road this season.
For a third straight game, St. Louis took the lead for good in the second inning. David Freese singled, took second on a walk to Yadier Molina and scored on a single by Tony Cruz. Skip Schumaker followed with a sacrifice fly.
The Cardinals made it 4-0 in the third when Matt Holliday doubled and Berkman drove a 1-2 pitch into the seats in left.
In the fourth, Ryan Theriot singled in a run and Jay hit his sixth homer with two aboard to chase Matusz, who was booed by many in the crowd of 28,340.
The next time Matusz throws in a game, it will be at the Triple-A level.
"I think he needs to get the ball every fifth day and continue to work on some things that he's aware of," Orioles manager Buck Showalter said. "It's a tough time for him. He's a young man who hasn't had much failure pitching in his career, but just about everybody does at some point. It's how you handle it."
Reimold hit a three-run homer in the fourth and Reynolds ended Garcia's night with a two-run drive in the sixth.
Berkman made it 9-5 with his 20th home run of the season, off Alfredo Simon, and Reimold singled in a run in the eighth.
NOTES: The Cardinals' last previous sweep of an AL East opponent on the road came at Tampa Bay in 2005. St. Louis closes interleague play with a three-game series at the Rays this weekend. ... Baltimore designated hitters have only one home run in the last 27 games ... Theriot went 2 for 5, his team-high 26th multihit game. ... Garcia had only one perfect inning, but was backed by three double plays.
[Associated Press;
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