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The Cubs rallied in the bottom of the eighth. Byrd led off with a single off Astros reliever Wilton Lopez and he advanced to third on Soto's single. Alfonso Soriano tied the game with a broken-bat single to left.
Cubs reliever Carlos Marmol pitched out of a one-out bases loaded jam in the ninth. He struck out Pence then ended the inning by getting Lee to pop out to center.
Soto and Barney had a pair of RBI doubles for the Cubs, who swept an opponent at home for the first time since taking three straight from Cincinnati on July 24-26, 2009.
The last time the Cubs won three straight overall was at San Diego and Houston on Sept. 30-Oct. 2, 2010.
Garza allowed two runs on five hits over seven innings, while striking out nine. He hasn't won since July 27.
Clint Barmes also hit a solo home run for the major-league worst Astros, who have lost seven straight on the road.
Astros starter Jordan Lyles rebounded after a three-run second inning to pitch six innings. The 20-year-old allowed three runs and nine hits while striking out five.
Trailing 1-0 in the second inning, Byrd led off with a double and scored on Soto's double to center field. After Soriano struck out, Barney doubled down the right-field line to score Soto. Garza followed with a single to right to score Barney to give the Cubs a 3-1 lead. It was Garza's first RBI in the majors.
Barmes' first inning home run ended Houston's streak of 27 consecutive hits without an extra base hit. Barmes connected on Garza's 1-1 pitch in the first inning for his sixth of the season.
"We went out there and battled, battled, battled. Lyles kept us in the game and pitched a great game. The bullpen has been great for us. It's one of those situation that seems like nothing goes right, no matter what. Always something is going to happen. It doesn't matter how good we play," said Lee.
NOTES: Astros C Carlos Corporan, who left the game after getting hit on the right foot by a pitch on Saturday, suffered a bruise, but isn't expected to miss extended time.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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