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Seattle finally broke through in the sixth, scoring three runs to snap Floyd's streak and take a 3-1 lead. Franklin Gutierrez's two-run double highlighted the inning and Kennedy drove in the other run on a grounder.
That was the last inning for Floyd, who threw six innings and allowed five hits, three runs and three walks and struck out three.
Chicago pulled within a run on Gordon Beckham's two-out RBI single in the bottom of seventh.
The Mariners tacked on a run in the eighth when Olivo's homer made it 4-2. Olivo also scored Seattle's last run, when he came home on Gutierrez's squeeze bunt in the 10th.
Quentin erased that lead in the bottom of the inning.
"(Quentin) is just a professional hitter," Vargas said. "He frustrates me as much as I frustrate him. ... He puts you in a position where you have to come to him. You just try to keep guys off base for when he comes to the plate."
The White Sox slugger came in leading the majors in extra-base hits (35) and doubles (20). His eighth-inning homer was his 17th of the season, and gave him 13 career multi-homer games, including three this season.
Chicago got to Vargas in the first inning. Quentin hit a 1-2 pitch into the back of the White Sox bullpen in left field, extending his hitting streak to 10 games.
Vargas retired the next nine Chicago batters, before Paul Konerko doubled in the fourth.
"I was pleased with the way I was able to throw the fastball, especially early," Vargas said. "That kind of set the tone for me."
NOTES: The White Sox placed RHP Jake Peavy on the 15-day disabled list (retroactive to Monday) with a mild groin strain. Peavy, who left his most recent start after four innings because of the injury, was replaced on the roster by RHP Lucas Harrell, who was recalled from Triple-A Charlotte. ... Alex Rios was back in the starting lineup on Wednesday after sitting for three games for what White Sox manager Ozzie Guillen called a "mental break." Rios is hitting .199 on the season. ... Suzuki played his 1,353rd career game in right field for the Mariners, breaking Jay Buhner's franchise record. ... Jeff Marquez, designated for assignment on June 5 by the White Sox, was claimed off waivers by the Yankees on Wednesday.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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