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Holliday led off the eighth with his second double of the game and scored on Yadier Molina's fly ball to right field off Cory Gearrin.
Garcia gave up five hits and four runs in six-plus innings.
Nick Punto and Colby Rasmus reached on singles and scored on Holliday's double to left in the first. Berkman added a run-scoring single to center.
Lowe settled down with three strong innings before the Cardinals pushed the lead to 4-0 in the fifth when Pujols drove in Garcia with a single up the middle.
After Garcia threw four perfect innings to open the game, the Braves broke through in the fifth when Brian McCann singled and scored on the homer by Gonzalez. Mather walked, moved to third on McLouth's broken-bat single and scored on pinch-hitter Brandon Hicks' single to left.
The Cardinals couldn't score after loading the bases against Scott Linebrink with no outs in the sixth. Berkman, who led off the inning with a single, was thrown out at the plate on Theriot's grounder to third baseman Chipper Jones. Brian McCann threw to first to complete the double play, and George Sherrill struck out Garcia to end the inning.
Pujols moved from first base to third base in the eighth. It was his first appearance at third base since Sept. 23, 2002 against Arizona. Mark Hamilton entered the game at first base in a double-switch as manager Tony La Russa brought right-hander Ryan Franklin in to pitch.
NOTES: Hicks' pinch-hit single was his first major league hit. ... Punto left the game in the fourth inning due to tightness in his left hamstring. Daniel Descalso replaced Punto at second base. ... The attendance was 34,129, including 559 dogs for Bark at the Park day.
[Associated Press;
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