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Frank Gore started despite a right knee injury that knocked him out of a win over the New York Giants a week earlier, finishing with 88 yards rushing. He needs 61 more to pass the late Joe Perry (7,344) for San Francisco's career rushing mark.
The slick, sloppy surface at the start gave way to several slips.
David Akers had been one of the NFL's most reliable kickers -- making 15 straight field goals -- until a field flooded with water soaked his streak. He converted field goals from 43, 29 and 22 yards in the first half but had two kicks blocked and pulled another wide right.
Calais Campbell swatted the first attempt from 46 yards and Patrick Peterson blocked one from 30 yards. After Willis intercepted a pass by Skelton, the 49ers' offense stalled and Akers lost his footing and sent a 49-yard attempt wide right.
The defense again gave San Francisco a short field when Willis stripped the ball from Beanie Wells and the 49ers recovered. Wells was originally ruled down before the call was overturned on a challenge.
Braylon Edwards dropped a short pass in the end zone on third down and forced another 49ers kick. Later, Smith converted a fourth-and-2 from the Arizona 31 with an 11-yard completion to Williams, setting up a 29-yard field goal by Akers that gave San Francisco a 9-0 lead at the half.
The 49ers regained their rhythm in the second half and the one hiccup Smith showed came late.
He seemed to misread coverage and lofted a short pass that was intercepted in the end zone by Darryl Williams in the fourth quarter.
Smith completed 20 of 38 passes in one of his best games of the season. The only time he threw for more this season was when he had 291 yards in a win at Philadelphia.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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