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Jason Grilli (2-1) worked a perfect eighth for the win.
"We gave them a chance to come back, and they came back and beat us," Cardinals manager Tony La Russa said.
Pujols' home run off Brad Lincoln after Jon Jay led off the sixth with a single gave the Cardinals their only lead. It was the 443rd homer of his career, moving him into sole possession of 37th place.
Pujols, who also had a sacrifice fly in the first, has hit safely in 10 of 11 games played this month and has four homers in his past 12 games. It was his third home run in seven games this season at PNC Park, his 29th career there -- most of any opposing player at the 11-year-old stadium and the most for him at any park not in St. Louis.
But the Cardinals' bullpen deprived Lohse of his sixth win in his past seven decisions and of the opportunity to improve to 8-2 in his career against the Pirates. Lohse allowed three runs on eight hits and a walk with three strikeouts.
Lincoln entered having allowed seven runs in four starts since permanently being put into the rotation Aug. 22. He endured his worst outing of the season, allowing four runs (three earned) on eight hits and two walks in 5 1-3 innings.
The Cardinals had 15 baserunners in the game but were hurt by grounding into two double plays and being caught stealing twice.
"We had several chances to get a little more -- or a lot more -- than we got, but they prevented that," La Russa said. "And we had a couple of chances to give up less than we did and we didn't."
NOTES: Pittsburgh has had a starter pitch more than six innings only once in its past 21 games. ... St. Louis' most recent six-game winning streak in September came in 2008. ... The Cardinals are closing in on agreeing to a $21 million, two-year contract with RHP Chris Carpenter, who will start Tuesday. He is 12-3 lifetime against the Pirates but 1-2 in four starts this season. ... RHP Jeff Karstens will start for Pittsburgh, his first outing since Aug. 28 at St. Louis. He had his past two starts skipped due to shoulder stiffness.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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