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Tyler Flowers hit a solo homer, his fifth of the season, off Henderson Alvarez (1-3) in the second. A.J. Pierzynski singled home a run in the sixth.
Toronto's Mike McCoy greeted Jesse Crain with his second homer to cut the lead to 2-1.
Chris Sale got the final five outs to earn his eighth save in nine chances.
Alvarez allowed seven hits in seven innings.
Blue Jays manager John Farrell also lauded Buehrle.
"Tonight was a game he's probably pitched many, many times with his career with the White Sox. A lot of zeros. A quick paced game. A lot of strikes," Farrell said.
"Just a true professional who went about his work as we've seen over a course of a number of years. Just an outstanding game on his part."
Dunn went 0 for 3 with three strikeouts, dropping his average to .159 with a franchise-record 177 strikeouts. Dunn needs six plate appearances in the final game to finish with the worst qualifying batting average in modern big league history, surpassing Rob Deer's .179 mark in 1991.
NOTES: White Sox RHP Phil Humber (9-9) makes his 28th appearance and 26th start in Wednesday's season finale. Humber is 1-5 with a 6.15 ERA in his last 10 starts. He is 0-0 with a 4.50 ERA in three career games, including a start, against the Blue Jays. Toronto counters with Brandon Morrow (11-11), whose 10.18 strikeouts per nine innings leads the American League. ... Omar Vizquel, at age 44, said he'd like to play another season, but is not sure if he'll try to follow Guillen to Florida -- should he become Marlins manager -- or maybe stick with the White Sox another season. He did attend Guillen's final news conference Monday to show support for his fellow Venezuelan. ... Toronto's Edwin Encarnacion has an inflamed nerve in his left shoulder but no structural problems. He has not been ruled out of Wednesday's season finale. ... Pierzynski reached 1,000 innings caught for the 10th straight season. ... Dave Nicholson struck out 175 times for the White Sox in 1963.
[Associated Press;
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