The play, a return to the story by Truman Capote, will star Emilia Clarke of HBO's "Game of Thrones" in the role Audrey Hepburn made famous in 1961 movie.
Performances at the Cort Theatre begin March 4.
Wendt, former "Cheers" dude-at-the-bar Norm Peterson, is no stranger to the stage. He was last on Broadway as Santa in a musical made from the Will Ferrell film "Elf."
He also slipped on Edna Turnblad's housecoat in Broadway's "Hairspray" beginning in 2007, and was in the Tony Award-winning play "Art" in New York and London; he starred in the national tour of "12 Angry Men"; and appeared in a production of David Mamet's "Lakeboat."