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Austin had 11 receptions, scoring on passes of 8, 27, 3 and 37 yards.
"I do know who the fastest kid on the field was," Holgorsen said. "We made a conscious effort to get him the ball a bunch, and whenever we got him the ball, he made things happen."
Clemson couldn't keep up with the Big East Conference co-champions, although Andre Ellington did score the game's first points on a 68-yard run. First-team All-Americans Sammy Watkins and Dwayne Allen combined for only seven catches for 87 yards.
"We didn't play too good," Watkins said. "We've got the whole next year to get right."
Amid the flurry of points, defensive back Cook came up with second-longest play in Orange Bowl history.
Clemson was on the verge of taking the lead in the second quarter when Ellington ran up the middle and disappeared into a heap at the 1. A teammate signaled touchdown, but the ball came loose and Cook grabbed it, then took off with nothing but the end zone in front of him.
"Cook was the only one in the stadium who knew the ball was out," teammate Bruce Irvin said. "That was a heads-up play."
The potential 14-point swing seemed to deflate the Tigers, who had moved the ball almost at will to that point.
"They hadn't really stopped us," Swinney said. "That was huge. Then it snowballed quickly."
The Tigers were doomed when quarterback Tajh Boyd committed turnovers on consecutive Clemson plays.
After Smith ran 7 yards on a keeper for a 35-20 lead, Pat Miller intercepted Boyd's pass. Smith flipped a 1-yard touchdown pass to Austin and, on the next play a call was overturned, with the replay official determining Boyd had lost a fumble.
Alston then ran for a 1-yard touchdown with 4 seconds left in the half.
"Momentum swung not in our favor, and it was hard to recapture," Boyd said. "West Virginia is a great offense. You can't really get behind them. We couldn't stop them. Guys were gassed. Their legs were going. It was a tough loss -- pretty embarrassing."
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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