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Addison Reed worked out of trouble in the ninth for his sixth save. Pena drew a leadoff walk, with pinch-runner Rich Thompson advancing to second on Matt Joyce's one-out single. Zobrist and Scott then both popped out to shallow left.
"Anytime we get out there with a lead, we want to shut it down, but especially with everything that happened early on in the game you kind of want it a little more, to really shut the door on them," Reed said.
Pena hit a two-run homer off Nate Jones (3-0) in the sixth.
Alex Rios hit a first-inning RBI single. Tampa Bay tied it at 1 on Scott's opposite-field homer to left in the second.
Cobb worked out of a bases-loaded, no-out jam in the second. After Alejandro De Aza hit a grounder and Beckham struck out, Adam Dunn hit a fly to center that B.J. Upton caught on the warning track.
Quintana allowed one run and one hit in 3 2-3 innings. Cobb gave up four runs and nine hits over five innings.
De Aza left in the sixth when he was hit near the right knee by the ball while diving back to second on J.P. Howell's pickoff attempt.
NOTES: Tampa Bay DH-LF Hideki Matsui was out of the lineup one day after homering in his Rays' debut. He entered in the sixth and went 0 for 2. ... Matsui will earn $615,519 from his contract with the Rays if he stays on the 40-man roster for the rest of the season. Matsui was put on the 40-man roster Tuesday, meaning he will earn 128 days of major league pay from the 183-day season. His contract lists an $880,000 salary while in the majors and a $250,000 salary while in the minors. ... White Sox LHP John Danks (strained left shoulder) threw at 60 feet on level ground and could rejoin the rotation early next week. ... Chicago 3B Brent Morel (lower back strain) is set to start a minor league rehab assignment with Triple-A Charlotte. ... Rays OF Desmond Jennings (sprained left knee) is scheduled to start playing in minor league rehab games Thursday.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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