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Fowler, who had a game-ending RBI triple among his team record-tying seven hits in Monday's doubleheader sweep of Houston, doubled and scored in the second inning and had a three-run homer off reliever Rhiner Cruz in the sixth for his career-high eighth home run of the season.
"The home runs were the difference," Astros manager Brad Mills said. "Five home runs with the first being a grand slam. We battled back and had a lot of hits. But they won it. They got the five homers."
Harrell, who outdueled the Dodgers' Clayton Kershaw in a 3-1 victory last time out, gave up a career-high nine runs on 10 hits in five innings. He struck out four and walked three.
Christian Friedrich (3-1) allowed five runs on 11 hits in six innings, shaking off a rough third inning in which the Astros scored four runs.
Chris Snyder had a two-run double, Chris Johnson had a sacrifice fly and Justin Maxwell added an RBI single as the Astros pulled into a 5-5 tie. But Houston couldn't sustain the momentum, losing its fifth in a row and its sixth straight to the Rockies at Coors Field.
The Rockies' run total was the highest allowed by the Astros this season, surpassing the previous high of nine, which the Astros had done twice this season, most recently in a 9-7 loss to Colorado in the opener of Monday's doubleheader.
NOTES: Prior to the game, the Rockies designated LHP Jamie Moyer for assignment and recalled pitcher Carlos Torres from Triple-A Colorado Springs. The Rockies have 10 days to trade or release the 49-year-old Moyer, who became the oldest pitcher to win as a starter when he beat the San Diego Padres on April 17. ... The Astros send RHP Bud Norris (5-1) against Colorado's Jeremy Guthrie (2-3) in Thursday's finale of the four-game series. Norris has gone 4-0 with a major-league low 1.17 ERA in five previous starts during May. ... Cuddyer has two of the Rockies' four grand slams this season. He hit his first on May 5 against Atlanta.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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