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Last year, Federer defeated Djokovic at that stage, ending the Serb's 43-match winning streak. And if they meet at Roland Garros again this year, Djokovic will have another streak on the line.
The top-ranked Serb, who beat Blaz Kavcic of Slovenia 6-0, 6-4, 6-4 Tuesday, has won 23 straight Grand Slam matches and needs five more to win his fourth straight major title.
"Everything is working great," Djokovic said. "You know, I'm feeling better and better every match."
For Venus Williams, things aren't going as smoothly. Although she has never won the French Open, the 31-year-old American has always been considered a contender at every Grand Slam tournament.
That all changed last year.
Williams withdrew before her second-round match at the U.S. Open, revealing that she had been diagnosed with Sjogren's syndrome, a condition that can cause fatigue and joint pain.
She needed three sets to win in the first round Sunday, and never really looked like challenging Radwanska this time.
"When I lose a match, I don't really like to get into ... any of those other things," Williams said when asked about her health situation. "It's just important to give credit to the people who won. And I didn't win."
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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